Concepedia

Complement System

The Complement System is a tightly regulated enzyme cascade of serum proteins in the vertebrate immune system that functions as a fundamental effector mechanism of innate immunity by recognizing, opsonizing, and eliminating pathogens through direct lysis, inflammation, and immune complex clearance.

23.9K

Publications

1.4M

Citations

72.5K

Authors

7.5K

Institutions

Publications per year

2017–2026

2.8K

Variants

Complement Cascade

Parents

Children

Publications

23.9K

Complement Factor H Polymorphism in Age-Related Macular Degeneration

Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew et al. · Science · 2005 · 4.5K citations

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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman et al. · Neuron · 2012 · 4.1K citations · Full text

, , +14

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong, Victoria F. Beja-Glasser, Bianca M. Nfonoyim et al. · Science · 2016 · 3.4K citations · Full text

, , +17

The Classical Complement Cascade Mediates CNS Synapse Elimination

Beth Stevens, Nicola J. Allen, Luis E Vazquez et al. · Cell · 2007 · 3.3K citations · Full text

, , +10

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Philipp E. Scherer, Suzanne Williams, M Fogliano et al. · Journal of Biological Chemistry · 1995 · 3.2K citations · Full text

, , +17

1–5 of 23.9K

Authors

72.5K

  1. JD
    John D. Lambris

    University of Pennsylvania, United States

    286 publications · 31.7K citations

    95

    h-index

  2. HJ
    Hans J. Müller‐Eberhard

    Scripps Health, United States

    166 publications · 20.6K citations

    83

    h-index

  3. BP
    B. Paul Morgan

    Cardiff University, United Kingdom

    294 publications · 21.3K citations

    81

    h-index

  4. PF
    Peter F. Zipfel

    Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI), Germany

    173 publications · 16.1K citations

    79

    h-index

  5. VM
    V. Michael Holers

    University of Colorado Denver, United States

    187 publications · 17.5K citations

    72

    h-index

1–5 of 72.5K

Institutions

7.5K

  1. Harvard University

    Cambridge, United States

    132 h-index

    2.3K publications

    297.8K citations

  2. National Institutes of Health

    Bethesda, United States

    109 h-index

    1.4K publications

    122.2K citations

  3. University of Pennsylvania

    Philadelphia, United States

    107 h-index

    1.4K publications

    123.7K citations

  4. University of Oxford

    Oxford, United Kingdom

    99 h-index

    987 publications

    91.1K citations

  5. Scripps Clinic

    La Jolla, United States

    94 h-index

    839 publications

    78.2K citations

  6. Washington University in St. Louis

    St Louis, United States

    94 h-index

    1.2K publications

    119K citations

  7. Scripps Health

    San Diego, United States

    94 h-index

    964 publications

    83.8K citations

  8. Brigham and Women's Hospital

    Boston, United States

    90 h-index

    971 publications

    114.3K citations

1–8 of 7.5K

Venues

  1. The Journal of Experimental Medicine

    637 publications · 91.6K citations

    173

    h-index

  2. The Journal of Immunology

    JI · 2.4K publications · 160.1K citations

    169

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 415 publications · 58.6K citations

    136

    h-index

  4. Journal of Clinical Investigation

    JCI · 414 publications · 51.8K citations

    130

    h-index

  5. PubMed

    Repository · 2.4K publications · 93.6K citations

    115

    h-index

1–5