Concepedia

Complement-targeted Therapy

Complement-Targeted Therapy is a therapeutic strategy within immunopharmacotherapy that modulates the complement system, an integral component of the innate immune response, to treat diseases characterized by dysregulated or excessive complement activation.

662

Publications

44.5K

Citations

5.1K

Authors

1.3K

Institutions

Publications per year

2017–2026

304

Parents

Children

Publications

662

The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen, Neal S. Young, Jörg Schubert et al. · New England Journal of Medicine · 2006 · 1.3K citations · Full text

, , +17

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

Paul W. Dempsey, Michael Allison, Srinivas Akkaraju et al. · Science · 1996 · 1.2K citations

, , +14

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

Russell P. Rother, Scott A. Rollins, Christopher F. Mojcik et al. · Nature Biotechnology · 2007 · 764 citations

, , +13

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria

Robert A. Brodsky, Neal S. Young, Elisabetta Antonioli et al. · Blood · 2007 · 653 citations

, , +11

Effect of Eculizumab on Hemolysis and Transfusion Requirements in Patients with Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen, Claire Hall, Judith Marsh et al. · New England Journal of Medicine · 2004 · 637 citations · Full text

, , +17

1–5 of 662

Authors

5.1K

  1. ST
    Stephen Tomlinson

    Medical University of South Carolina, United States

    34 publications · 2.1K citations

    26

    h-index

  2. AM
    Antonio M. Risitano

    University of Naples Federico II, Italy

    21 publications · 4.6K citations

    20

    h-index

  3. JD
    John D. Lambris

    University of Pennsylvania, United States

    21 publications · 1.8K citations

    19

    h-index

  4. AR
    Alexander Röth

    University of Duisburg-Essen, Germany

    19 publications · 3.2K citations

    18

    h-index

  5. HS
    Hubert Schrezenmeier

    Universität Ulm, Germany

    15 publications · 3.7K citations

    15

    h-index

1–5 of 5.1K

Institutions

1.3K

  1. Alexion Pharmaceuticals (United States)

    Boston, United States

    35 h-index

    206 publications

    28.3K citations

  2. Medical University of South Carolina

    Charleston, United States

    27 h-index

    168 publications

    8.9K citations

  3. University of Pennsylvania

    Philadelphia, United States

    23 h-index

    97 publications

    7.2K citations

  4. University of Colorado Denver

    Denver, United States

    21 h-index

    45 publications

    2.3K citations

  5. University College London

    London, United Kingdom

    19 h-index

    43 publications

    2.5K citations

  6. Harvard University

    Cambridge, United States

    18 h-index

    69 publications

    4.4K citations

  7. Assistance Publique – Hôpitaux de Paris

    Paris, France

    18 h-index

    61 publications

    7.6K citations

  8. University of Duisburg-Essen

    Essen, Germany

    16 h-index

    27 publications

    1.6K citations

1–8 of 1.3K

Venues

  1. Blood

    42 publications · 4.5K citations

    25

    h-index

  2. The Journal of Immunology

    JI · 26 publications · 1.4K citations

    20

    h-index

  3. Blood Advances

    14 publications · 667 citations

    14

    h-index

  4. Frontiers in Immunology

    15 publications · 483 citations

    14

    h-index

  5. Kidney International Reports

    12 publications · 515 citations

    12

    h-index

1–5