Concepedia

Complement Pharmacokinetics

Complement Pharmacokinetics is a pharmacokinetic framework that specifically characterizes the absorption, distribution, metabolism, and excretion dynamics of therapeutic agents targeting the complement system, distinguishing it from general pharmacokinetics by its focus on complement-modulating biologics and their interactions within immune-mediated pathways.

41

Publications

2.4K

Citations

292

Authors

97

Institutions

Publications per year

2017–2026

16

Parents

Publications

41

Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass

Jane C.K. Fitch, Scott A. Rollins, Louis A. Matis et al. · Circulation · 1999 · 284 citations · Full text

, , +17

Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey

W M Galbraith, W. Hobson, Patricia C. Giclas et al. · Antisense Research and Development · 1994 · 237 citations

, , +16

The clearance of tetanus toxoid/anti-tetanus toxoid immune complexes from the circulation of humans. Complement- and erythrocyte complement receptor 1-dependent mechanisms.

Jürg A. Schifferli, Y C Ng, J Estreicher et al. · The Journal of Immunology · 1988 · 152 citations

, , +14

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Pirow Bekker, Daniel J. Dairaghi, Lisa Seitz et al. · PLoS ONE · 2016 · 150 citations · Full text

, , +17

Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation

Sonata Jodele, Tsuyoshi Fukuda, Kana Mizuno et al. · Biology of Blood and Marrow Transplantation · 2015 · 139 citations · Full text

, , +17

1–5 of 41

Authors

292

  1. ES
    Edimara S. Reis

    University of Pennsylvania, United States

    3 publications · 186 citations

    3

    h-index

  2. JD
    John D. Lambris

    University of Pennsylvania, United States

    3 publications · 186 citations

    3

    h-index

  3. LM
    Lori Morton

    Regeneron (United States), United States

    2 publications · 41 citations

    2

    h-index

  4. SO
    Stephan Ortiz

    Alexion Pharmaceuticals (United States), United States

    2 publications · 85 citations

    2

    h-index

  5. AB
    Anna Borodovsky

    Alnylam Pharmaceuticals (United States), United States

    2 publications · 98 citations

    2

    h-index

1–5 of 292

Institutions

97

  1. Alexion Pharmaceuticals (United States)

    Boston, United States

    6 h-index

    36 publications

    6K citations

  2. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    15 publications

    1.2K citations

  3. University of Milan

    Milan, Italy

    3 h-index

    8 publications

    170 citations

  4. King's College Hospital

    London, United Kingdom

    2 h-index

    2 publications

    89 citations

  5. Alexion Pharma (Switzerland)

    Zurich, Switzerland

    2 h-index

    20 publications

    5.4K citations

  6. Hammersmith Hospital

    London, United Kingdom

    2 h-index

    8 publications

    664 citations

  7. Regeneron (United States)

    Tarrytown, United States

    2 h-index

    18 publications

    367 citations

  8. Stanford University

    Stanford, United States

    2 h-index

    21 publications

    5.5K citations

1–8 of 97

Venues

  1. PLoS ONE

    3 publications · 183 citations

    3

    h-index

  2. PubMed

    Repository · 2 publications · 32 citations

    2

    h-index

  3. 2

    h-index

  4. Blood

    2 publications · 44 citations

    2

    h-index

  5. Antisense Research and Development

    1 publications · 237 citations

    1

    h-index

1–5