Concepedia

Complement Pharmacodynamics

Complement Pharmacodynamics is a pharmacological framework that characterizes the biochemical and physiological effects of complement-targeted therapeutic agents, specifically delineating the relationship between their concentration and the magnitude of complement system modulation.

25

Publications

1.4K

Citations

241

Authors

110

Institutions

Publications per year

2017–2026

15

Parents

Publications

25

Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass

Jane C.K. Fitch, Scott A. Rollins, Louis A. Matis et al. · Circulation · 1999 · 284 citations · Full text

, , +17

Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation

Sonata Jodele, Tsuyoshi Fukuda, Kana Mizuno et al. · Biology of Blood and Marrow Transplantation · 2015 · 139 citations · Full text

, , +17

Structure of and influence of a tick complement inhibitor on human complement component 5

Folmer Fredslund, N.S. Laursen, Pietro Roversi et al. · Nature Immunology · 2008 · 137 citations

, , +12

Structural basis for therapeutic inhibition of complement C5

Matthijs M. Jore, Steven Johnson, Devon Sheppard et al. · Nature Structural & Molecular Biology · 2016 · 117 citations · Full text

, , +15

Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial

Ulrich Jäger, Shirley D’Sa, Christian Schörgenhofer et al. · Blood · 2018 · 110 citations · Full text

, , +17

1–5 of 25

Authors

241

  1. BJ
    Bernd Jilma

    Medical University of Vienna, Austria

    3 publications · 146 citations

    3

    h-index

  2. SD
    Shirley D’Sa

    University College London, United Kingdom

    3 publications · 146 citations

    3

    h-index

  3. AB
    Anna Borodovsky

    Alnylam Pharmaceuticals (United States), United States

    3 publications · 115 citations

    3

    h-index

  4. CM
    Catherine M. Broome

    Georgetown University, United States

    2 publications · 36 citations

    2

    h-index

  5. MA
    Miles A. Nunn

    UK Centre for Ecology & Hydrology, United Kingdom

    2 publications · 254 citations

    2

    h-index

1–5 of 241

Institutions

110

  1. Alexion Pharmaceuticals (United States)

    Boston, United States

    5 h-index

    31 publications

    5.8K citations

  2. Alnylam Pharmaceuticals (United States)

    Cambridge, United States

    3 h-index

    13 publications

    645 citations

  3. Medical University of Vienna

    Vienna, Austria

    3 h-index

    5 publications

    366 citations

  4. University College London

    London, United Kingdom

    3 h-index

    3 publications

    146 citations

  5. University of Oxford

    Oxford, United Kingdom

    3 h-index

    12 publications

    1.1K citations

  6. Harvard University

    Cambridge, United States

    3 h-index

    3 publications

    69 citations

  7. Privatsykehuset Haugesund

    Haugesund, Norway

    2 h-index

    2 publications

    36 citations

  8. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, Italy

    2 h-index

    2 publications

    36 citations

1–8 of 110

Venues

  1. Blood

    3 publications · 143 citations

    3

    h-index

  2. Nucleic Acid Therapeutics

    1 publications · 28 citations

    1

    h-index

  3. Nature Nanotechnology

    1 publications · 38 citations

    1

    h-index

  4. Nature Structural & Molecular Biology

    1 publications · 117 citations

    1

    h-index

  5. Journal of Immunological Methods

    1 publications · 27 citations

    1

    h-index

1–5