Concepedia

High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains

Elvin D. de Araujo, Pimyupa Manaswiyoungkul, Johan Israelian, Jisung Park, Karen K. Y. Yuen, Shiva Farhangi, Angelika Berger‐Becvar, Lubna Abu-Jazar, Patrick T. Gunning

Journal of Pharmaceutical and Biomedical Analysis · 2017 · 16 citations · 27 references

DOI

Concepts

References

27

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

, , +16

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

F. Niesen, H. Berglund, Masoud Vedadi · Nature Protocols · 2007 · 2.4K citations

, , +14

Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization

Jochen Schust, Bianca Sperl, Angela Hollis et al. · Chemistry & Biology · 2006 · 1.1K citations

, , +11

A relationship between protein stability and protein function.

B.K. Shoichet, W.A. Baase, Ryota Kuroki et al. · Proceedings of the National Academy of Sciences · 1995 · 735 citations

, , +17

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

Hui Song, Renxiao Wang, Shaomeng Wang et al. · Proceedings of the National Academy of Sciences · 2005 · 499 citations · Full text

, , +11