Concepedia

Sh2 Domains

SH2 Domain is a type of protein interaction domain that specifically recognizes and binds to phosphorylated tyrosine residues within target proteins, thereby mediating signal transduction pathways in cellular processes.

2.2K

Publications

193K

Citations

8.8K

Authors

1.5K

Institutions

Publications per year

2017–2026

186

Parents

Publications

2.2K

SH2 domains recognize specific phosphopeptide sequences

Cell · 1993 · 2.7K citations

, , +14

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Christine Koch, Deborah H. Anderson, Michael F. Moran et al. · Science · 1991 · 1.9K citations

, , +17

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Eve J. Lowenstein, Roger J. Daly, Andreas Batzer et al. · Cell · 1992 · 1.7K citations · Full text

, , +17

A new protein containing an SH2 domain that inhibits JAK kinases

Takaho A. Endo, Masaaki Masuhara, Masahiro Yokouchi et al. · Nature · 1997 · 1.4K citations

, , +16

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

Giuliana Pelicci, Luisa Lanfrancone, F Grignani et al. · Cell · 1992 · 1.3K citations

, , +14

1–5 of 2.2K

Authors

8.8K

  1. TP
    Tony Pawson

    Mount Sinai Hospital, Canada

    68 publications · 13.2K citations

    49

    h-index

  2. SE
    Steven E. Shoelson

    Joslin Diabetes Center, United States

    42 publications · 7.3K citations

    36

    h-index

  3. JS
    Joseph Schlessinger

    New York University, United States

    39 publications · 8.8K citations

    34

    h-index

  4. LC
    Lewis C. Cantley

    Harvard University, United States

    37 publications · 5.9K citations

    31

    h-index

  5. BG
    Benjamin G. Neel

    Harvard University, United States

    31 publications · 6.9K citations

    29

    h-index

1–5 of 8.8K

Institutions

1.5K

  1. Harvard University

    Cambridge, United States

    83 h-index

    562 publications

    84.3K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    61 h-index

    266 publications

    32.1K citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    52 h-index

    268 publications

    39.8K citations

  4. University of Toronto

    Toronto, Canada

    50 h-index

    284 publications

    32.6K citations

  5. Joslin Diabetes Center

    Boston, United States

    44 h-index

    189 publications

    30.6K citations

  6. National Institutes of Health

    Bethesda, United States

    42 h-index

    333 publications

    23.1K citations

  7. Mount Sinai Hospital

    Toronto, Canada

    42 h-index

    228 publications

    44.4K citations

  8. New York University

    New York, United States

    42 h-index

    184 publications

    43.3K citations

1–8 of 1.5K

Venues

  1. Journal of Biological Chemistry

    JBC · 473 publications · 44.2K citations

    118

    h-index

  2. Molecular and Cellular Biology

    MCB · 212 publications · 28.6K citations

    98

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 93 publications · 13.6K citations

    63

    h-index

  4. Biochemistry

    93 publications · 4.5K citations

    38

    h-index

  5. PubMed

    Repository · 69 publications · 3.6K citations

    36

    h-index

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