Concepedia

Inhibitor Screening

Inhibitor Screening is a methodological framework within enzyme screening that systematically identifies and characterizes molecules capable of selectively reducing the catalytic activity of target enzymes, distinguishing it from related approaches by its focused aim on discovering enzyme inhibitors for therapeutic or mechanistic investigation.

3.4K

Publications

145.1K

Citations

18.4K

Authors

3.2K

Institutions

Publications per year

2017–2026

1.2K

Parents

Publications

3.4K

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

Cai‐Hong Yun, Titus J. Boggon, Yiqun Li et al. · Cancer Cell · 2007 · 1.2K citations · Full text

, , +15

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

Susan L. McGovern, Emilia Caselli, Nikolaus Grigorieff et al. · Journal of Medicinal Chemistry · 2002 · 1K citations · Full text

, , +17

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

Haiyang Zhang, Ting Deng, Rui Liu et al. · Molecular Cancer · 2020 · 1K citations · Full text

, , +17

The computer program LUDI: A new method for the de novo design of enzyme inhibitors

Hans-Joachim B�hm · Journal of Computer-Aided Molecular Design · 1992 · 845 citations

, , +15

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Kylie M. Wagstaff, Haran Sivakumaran, Steven M. Heaton et al. · Biochemical Journal · 2012 · 684 citations · Full text

, , +14

1–5 of 3.4K

Authors

18.4K

  1. CT
    Claudiu T. Supuran

    University of Florence, Italy

    84 publications · 4.5K citations

    37

    h-index

  2. AS
    Andrea Scozzafava

    University of Florence, Italy

    33 publications · 2.5K citations

    26

    h-index

  3. DV
    Daniela Vullo

    University of Florence, Italy

    24 publications · 2K citations

    22

    h-index

  4. BK
    Brian K. Shoichet

    University of California, San Francisco, United States

    17 publications · 5.1K citations

    17

    h-index

  5. JI
    James Inglese

    National Institutes of Health, United States

    15 publications · 1.8K citations

    15

    h-index

1–5 of 18.4K

Institutions

3.2K

  1. University of Florence

    Florence, Italy

    38 h-index

    262 publications

    16.7K citations

  2. Scripps Research Institute

    San Diego, United States

    36 h-index

    286 publications

    22K citations

  3. Chinese Academy of Sciences

    Beijing, China

    34 h-index

    402 publications

    18.9K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    32 h-index

    296 publications

    12.9K citations

  5. National Institutes of Health

    Bethesda, United States

    29 h-index

    247 publications

    20.2K citations

  6. University of California, San Francisco

    San Francisco, United States

    26 h-index

    110 publications

    16.2K citations

  7. Inserm

    Paris, France

    22 h-index

    134 publications

    5.6K citations

  8. King Saud University

    Riyadh, Saudi Arabia

    22 h-index

    73 publications

    2.7K citations

1–8 of 3.2K

Venues

  1. Journal of Medicinal Chemistry

    296 publications · 22.4K citations

    78

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    130 publications · 4.1K citations

    37

    h-index

  3. Journal of Biological Chemistry

    JBC · 53 publications · 4.5K citations

    37

    h-index

  4. Bioorganic & Medicinal Chemistry

    88 publications · 3.2K citations

    35

    h-index

  5. Journal of the American Chemical Society

    JACS · 31 publications · 3.1K citations

    31

    h-index

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