Further development and validation of empirical scoring functions for structure-based binding affinity prediction

Renxiao Wang, Luhua Lai, Shaomeng Wang

Journal of Computer-Aided Molecular Design

The PDBbind Database:  Collection of Binding Affinities for Protein−Ligand Complexes with Known Three-Dimensional Structures

Renxiao Wang, Xueliang Fang, Yipin Lu, +1

Journal of Medicinal Chemistry

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Irfan A. Asangani, Vijaya L. Dommeti, Xiaoju Wang, +15

Nature

Radiation OncologyDrug TargetingAnti-cancer AgentTumor SuppressorProstatic Disease +4

The PDBbind Database:  Methodologies and Updates

Renxiao Wang, Xueliang Fang, Yipin Lu, +2

Journal of Medicinal Chemistry

EngineeringPdbbind DatabaseBig Data IndexingMolecular BiologyData Science +17

Comparative Evaluation of 11 Scoring Functions for Molecular Docking

Renxiao Wang, Yipin Lu, Shaomeng Wang

Journal of Medicinal Chemistry

Observed ConformationBiochemistryProtein FoldingMedicineProteomics +10

Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska, +9

Journal of Medicinal Chemistry

Combinatorial ChemistryMdm2-p53 InteractionChemoprevention StrategyChemical BiologyP53 Function +17

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern, +18

Proceedings of the National Academy of Sciences

Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska, +10

Journal of the American Chemical Society

Molecular DockingMedicinal ChemistryDrug TargetDrug DesignNatural P53 Peptide +13

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

Shunqiang Li, Dong Shen, Jieya Shao, +51

Cell Reports

Gene AmplificationBreast OncologyEngineeringPdx ModelsTumor Biology +16

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

Longchuan Bai, Haibin Zhou, Renqi Xu, +15

Cancer Cell

Cancer ResearchMedicineSmall MoleculesSelective Small-molecule DegraderTumor Targeting +7