Patrick T. Gunning

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

Xiaolei Zhang, Peibin Yue, Brent D. G. Page et al. · Proceedings of the National Academy of Sciences · 2012 · 349 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

An Oxazole-Based Small-Molecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects

Khandaker Siddiquee, Patrick T. Gunning, Matthew P. Glenn et al. · ACS Chemical Biology · 2007 · 186 citations · Full text

Medicine, Oncology, Pharmacology +13

A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes

Xiaolei Zhang, Peibin Yue, Steven Fletcher et al. · Biochemical Pharmacology · 2010 · 179 citations · Full text

Life Sciences, Molecular Biology, Oncology +7

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

Bettina Wingelhofer, Barbara Maurer, Elizabeth Heyes et al. · Leukemia · 2018 · 154 citations · Full text

Medicine, Oncology, Pharmacology +16

STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion

Dagmar Gotthardt, Eva Maria Putz, Eva Grundschober et al. · Cancer Discovery · 2016 · 150 citations

Life Sciences, Immunology, Oncology +17