Concepedia

3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone

Paul A. Brough, Xavier Barril, Mandy Beswick, Brian Dymock, Lisa Wright, Kate Grant, Andrew J. Massey, A.E. Surgenor, Paul Workman

Bioorganic & Medicinal Chemistry Letters · 2005 · 80 citations · 24 references

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Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider et al. · Cell · 1997 · 1.4K citations · Full text

, , +17

Hydrogen bonding and biological specificity analysed by protein engineering

Alan R. Fersht, Jianping Shi, J.W. Knill-Jones et al. · Nature · 1985 · 1.1K citations

, , +16

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

Wolfgang M.J. Obermann, Holger Sondermann, Alicia A. Russo et al. · The Journal of Cell Biology · 1998 · 605 citations · Full text

, , +15

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies

Udai Banerji, Anne O’Donnell, Michelle Scurr et al. · Journal of Clinical Oncology · 2005 · 491 citations · Full text

, , +17

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

Theodor W. Schulte, Leonard Μ. Neckers · Cancer Chemotherapy and Pharmacology · 1998 · 476 citations

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