Lisa Wright

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

Suzanne A. Eccles, Andy Massey, Florence I. Raynaud et al. · Cancer Research · 2008 · 469 citations

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Paul A. Brough, Wynne Aherne, Xavier Barril et al. · Journal of Medicinal Chemistry · 2007 · 442 citations · Full text

Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms

Lisa Wright, Xavier Barril, Brian Dymock et al. · Chemistry & Biology · 2004 · 265 citations · Full text

Hsp90 Isoforms, Signal Transduction, Biochemistry +5

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Brian Dymock, Xavier Barril, Paul A. Brough et al. · Journal of Medicinal Chemistry · 2005 · 231 citations · Full text

Crystal Structure, Drug Target, Molecular Biology +18

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-<i>d</i>]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

Paul A. Brough, Xavier Barril, Jenifer Borgognoni et al. · Journal of Medicinal Chemistry · 2009 · 173 citations · Full text