Theodor W. Schulte

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

James P. Grenert, W. Patrick Sullivan, Patrick Fadden et al. · Journal of Biological Chemistry · 1997 · 570 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

Theodor W. Schulte, Leonard Μ. Neckers · Cancer Chemotherapy and Pharmacology · 1998 · 476 citations

Pharmacy, Medicinal Chemistry, Pharmacology +2

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

Theodor W. Schulte, Mikhail V. Blagosklonny, Christian Ingui et al. · Journal of Biological Chemistry · 1995 · 457 citations · Full text

Life Sciences, Molecular Biology, Cell Signaling +9

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

Theodor W. Schulte, Shiro Akinaga, Shiro Soga et al. · Cell Stress and Chaperones · 1998 · 403 citations · Full text

Medicine, Pharmacology, Molecular Pharmacology +3

Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway

Theodor W. Schulte, Mikhail V. Blagosklonny, L.Y. Romanova et al. · Molecular and Cellular Biology · 1996 · 275 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17