Concepedia

Shiro Soga

SS

Statistics

Publications

16

Citations

1.3K

H-Index

14

Active since

1993

Affiliations

Kyowa Kirin (Japan)(Current)

National Cancer Institute

Kawasaki Medical School

Center for Cancer Research

Shiro Soga is an author at Kyowa Kirin (Japan) specializing in medicine, pharmacology, and molecular oncology.

Publications per year

1993–2012

16

Publications

16

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

Theodor W. Schulte, Shiro Akinaga, Shiro Soga et al. · Cell Stress and Chaperones · 1998 · 403 citations · Full text

, , +3

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

Shiro Soga, LM Neckers, T W Schulte et al. · PubMed · 1999 · 137 citations

, , +15

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

Yukimasa Shiotsu, Leonard Μ. Neckers, Ivo Wortman et al. · Blood · 2000 · 100 citations

, , +10

Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway

Shiro Soga, Takako Kozawa, Hiroaki Narumi et al. · Journal of Biological Chemistry · 1998 · 96 citations · Full text

, , +17

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

Akihiro Yano, Shinji Tsutsumi, Shiro Soga et al. · Proceedings of the National Academy of Sciences · 2008 · 94 citations · Full text

, , +16

1–5 of 16