Molecular Cell · 2013 · 206 citations · 19 references
Life SciencesGeneticsMolecular BiologyCell SignalingOncogenesSignal TransductionCell Signaling NetworksLigand BindingReceptor Tyrosine Kinase SignalingDimerization InhibitionDimerization-induced ActivationRaf SignalingRaf-mek-erk SignalingReceptor Dimerization
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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
Keith T. Flaherty, Igor Puzanov, Kevin B. Kim et al. · New England Journal of Medicine · 2010 · 3.5K citations
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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
Ramin Nazarian, Hubing Shi, Qi Wang et al. · Nature · 2010 · 2.2K citations
Medicine, Cancer Biology, Oncology +11
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
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Medicine, Cancer Biology, Oncology +15
Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
Sonja J. Heidorn, Carla Milagre, Steven R. Whittaker et al. · Cell · 2010 · 1.5K citations · Full text