Concepedia

Dimerization Inhibition

Dimerization Inhibition is a biochemical intervention strategy that specifically prevents the association of two protein monomers into a functional dimeric complex, thereby modulating protein activity or signaling pathways.

329

Publications

21.4K

Citations

2K

Authors

648

Institutions

Publications per year

2017–2026

80

Parents

Publications

329

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

Alexander Wlodawer, Maria Miller, Mariusz Jaskólski et al. · Science · 1989 · 1.2K citations

, , +17

Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization

Jochen Schust, Bianca Sperl, Angela Hollis et al. · Chemistry & Biology · 2006 · 1.1K citations

, , +11

Biology of HER2 and Its Importance in Breast Cancer

Yosef Yarden · Oncology · 2001 · 740 citations

, , +17

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-<i>fos</i>

Sohyun Ahn, Michelle Olive, Seema Aggarwal et al. · Molecular and Cellular Biology · 1998 · 505 citations · Full text

, , +14

Phase I Clinical Study of Pertuzumab, a Novel HER Dimerization Inhibitor, in Patients With Advanced Cancer

David B. Agus, Michael S. Gordon, Charles Taylor et al. · Journal of Clinical Oncology · 2005 · 388 citations · Full text

, , +7

1–5 of 329

Authors

2K

  1. JC
    Jean Chmielewski

    Purdue University West Lafayette, United States

    11 publications · 362 citations

    11

    h-index

  2. MR
    Michèle Reboud‐Ravaux

    Sorbonne Université, France

    9 publications · 262 citations

    9

    h-index

  3. FG
    Federico Gago

    Universidad de Alcalá, Spain

    5 publications · 125 citations

    5

    h-index

  4. DD
    Debananda Das

    National Institutes of Health, United States

    5 publications · 348 citations

    5

    h-index

  5. HM
    Hiroaki Mitsuya

    National Cancer Institute, United States

    5 publications · 348 citations

    5

    h-index

1–5 of 2K

Institutions

648

  1. Centre National de la Recherche Scientifique

    Paris, France

    19 h-index

    137 publications

    5.2K citations

  2. Purdue University West Lafayette

    West Lafayette, United States

    17 h-index

    52 publications

    2.6K citations

  3. National Institutes of Health

    Bethesda, United States

    13 h-index

    40 publications

    3.9K citations

  4. Sorbonne Université

    Paris, France

    11 h-index

    53 publications

    1.6K citations

  5. National Cancer Institute

    Bethesda, United States

    10 h-index

    33 publications

    3.2K citations

  6. Max Planck Society

    Munich, Germany

    10 h-index

    26 publications

    5.7K citations

  7. Harvard University

    Cambridge, United States

    9 h-index

    25 publications

    2.6K citations

  8. Max Planck Institute of Biochemistry

    Martinsried, Germany

    7 h-index

    17 publications

    6.7K citations

1–8 of 648

Venues

  1. Journal of Biological Chemistry

    JBC · 34 publications · 2.4K citations

    29

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.7K citations

    12

    h-index

  3. Journal of Medicinal Chemistry

    12 publications · 530 citations

    12

    h-index

  4. Journal of the American Chemical Society

    JACS · 11 publications · 1.1K citations

    11

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    11 publications · 295 citations

    11

    h-index

1–5