Concepedia

Dimerization-induced Activation

Dimerization-Induced Activation is a molecular mechanism in which the physical association of two protein subunits into a dimeric complex directly triggers or enhances the catalytic activity, signaling capability, or functional conformation of the associated proteins.

104

Publications

9.7K

Citations

593

Authors

185

Institutions

Publications per year

2017–2026

24

Parents

Publications

104

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

Neil Stahl, Teri G. Boulton, Thomas J. Farruggella et al. · Science · 1994 · 982 citations

, , +17

Chitin-Induced Dimerization Activates a Plant Immune Receptor

Tingting Liu, Zixu Liu, Chuanjun Song et al. · Science · 2012 · 673 citations

, , +17

A dimerization-dependent mechanism drives RAF catalytic activation

Thanashan Rajakulendran, Malha Sahmi, Martin Lefrançois et al. · Nature · 2009 · 498 citations

, , +3

Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction

Yukiko Gotoh, Jonathan A. Cooper · Journal of Biological Chemistry · 1998 · 355 citations · Full text

, , +14

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

Zhichao Wang, Myoung Kwon Choi, Tatsuma Ban et al. · Proceedings of the National Academy of Sciences · 2008 · 331 citations · Full text

, , +17

1–5 of 104

Authors

593

  1. DM
    David M. Spencer

    Baylor College of Medicine, United States

    4 publications · 268 citations

    4

    h-index

  2. HW
    Hong‐Hui Wang

    Hunan University, China

    3 publications · 205 citations

    3

    h-index

  3. ZN
    Zhou Nie

    Hunan University, China

    3 publications · 205 citations

    3

    h-index

  4. TS
    Tianhui Shi

    Wuhan University, China

    2 publications · 159 citations

    2

    h-index

  5. JM
    Jeffrey M. Rosen

    Baylor College of Medicine, United States

    2 publications · 97 citations

    2

    h-index

1–5 of 593

Institutions

185

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    14 publications

    1.7K citations

  2. Baylor College of Medicine

    Houston, United States

    5 h-index

    26 publications

    1.7K citations

  3. Harvard University

    Cambridge, United States

    4 h-index

    8 publications

    1.3K citations

  4. St. Jude Children's Research Hospital

    Memphis, United States

    3 h-index

    10 publications

    4.9K citations

  5. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    18 publications

    2.6K citations

  6. State Key Laboratory of Chemobiosensing and Chemometrics

    Changsha, China

    3 h-index

    19 publications

    1.3K citations

  7. Hunan University

    Changsha, China

    3 h-index

    19 publications

    1.3K citations

  8. Washington University in St. Louis

    St Louis, United States

    3 h-index

    10 publications

    356 citations

1–8 of 185

Venues

  1. Journal of Biological Chemistry

    JBC · 12 publications · 1.1K citations

    12

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 1.1K citations

    10

    h-index

  3. Biochemistry

    5 publications · 286 citations

    5

    h-index

  4. Biochemical Journal

    BJ · 4 publications · 315 citations

    4

    h-index

  5. Journal of the American Chemical Society

    JACS · 5 publications · 324 citations

    4

    h-index

1–5