Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

Proteasome Block, Biochemistry, Mhc Class +13

Structure of 20S proteasome from yeast at 2.4Å resolution

M. Groll, Lars Ditzel, Jan Löwe et al. · Nature · 1997 · 2.2K citations

Biochemistry, Natural Sciences, Medicine +5

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Gabriel Fenteany, Robert F. Standaert, William S. Lane et al. · Science · 1995 · 1.6K citations

Lactacystin Analogs, Lmp7 Proteasome Subunit, Protein Function +12

Crystal Structure of the 20 <i>S</i> Proteasome from the Archaeon <i>T. acidophilum</i> at 3.4 Å Resolution

Jan Löwe, Daniela Stock, Bing K. Jap et al. · Science · 1995 · 1.5K citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

Emmanuel J. H. J. Wiertz, Thomas R. Jones, Lei Sun et al. · Cell · 1996 · 1.1K citations · Full text

Virus Structure, Viral Replication, Pathogenesis +7