Concepedia

Protease-substrate Interactions

Protease-Substrate Interactions is a biochemical phenomenon in which a protease selectively recognizes and catalytically cleaves a specific substrate protein or peptide, distinguished by the molecular complementarity and binding specificity between the enzyme's active site and the substrate's cleavage sequence.

483

Publications

28.6K

Citations

2.1K

Authors

576

Institutions

Publications per year

2017–2026

65

Parents

Publications

483

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

Jennifer L. Harris, Bradley J. Backes, Francesco Leonetti et al. · Proceedings of the National Academy of Sciences · 2000 · 542 citations

, , +17

Cell‐Responsive Synthetic Hydrogels

Marco Lütolf, G. P. Raeber, Andreas H. Zisch et al. · Advanced Materials · 2003 · 519 citations · Full text

, , +17

Converting Trypsin to Chymotrypsin: The Role of Surface Loops

Lizbeth Hedstrom, László Szilágyi, William J. Rutter · Science · 1992 · 470 citations

, , +17

Mapping the active site of papain with the aid of peptide substrates and inhibitors

A. Berger, Israël Schechter · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1970 · 409 citations

, , +17

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

Robert S. Fuller, A J Brake, Jeremy Thorner · Proceedings of the National Academy of Sciences · 1989 · 393 citations · Full text

, , +17

1–5 of 483

Authors

2.1K

  1. CS
    Charles S. Craik

    University of California, San Francisco, United States

    10 publications · 1.5K citations

    10

    h-index

  2. MD
    Marcin Drąg

    Wrocław University of Science and Technology, Poland

    8 publications · 577 citations

    8

    h-index

  3. GS
    Guy S. Salvesen

    Sanford Burnham Prebys Medical Discovery Institute, United States

    8 publications · 655 citations

    8

    h-index

  4. CA
    Celia A. Schiffer

    University of Massachusetts Chan Medical School, United States

    8 publications · 584 citations

    8

    h-index

  5. CM
    Christopher M. Overall

    University of British Columbia, Canada

    7 publications · 614 citations

    7

    h-index

1–5 of 2.1K

Institutions

576

  1. University of California, San Francisco

    San Francisco, United States

    17 h-index

    56 publications

    7.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    29 publications

    1.5K citations

  3. Kyoto University

    Kyoto, Japan

    12 h-index

    29 publications

    1.3K citations

  4. University of Pennsylvania

    Philadelphia, United States

    12 h-index

    27 publications

    1.7K citations

  5. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    12 h-index

    45 publications

    4K citations

  6. Harvard University

    Cambridge, United States

    11 h-index

    41 publications

    5.3K citations

  7. Scripps Research Institute

    San Diego, United States

    11 h-index

    25 publications

    1.6K citations

  8. University of British Columbia

    Vancouver, Canada

    10 h-index

    37 publications

    3.3K citations

1–8 of 576

Venues

  1. Journal of Biological Chemistry

    JBC · 81 publications · 5.1K citations

    42

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 29 publications · 3.5K citations

    25

    h-index

  3. Biochemistry

    35 publications · 1.5K citations

    25

    h-index

  4. FEBS Letters

    10 publications · 451 citations

    10

    h-index

  5. Molecular Cell

    9 publications · 1.2K citations

    9

    h-index

1–5