Bradley J. Backes

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

Alana G. Lerner, John-Paul Upton, Paurush Praveen et al. · Cell Metabolism · 2012 · 812 citations · Full text

Inflammation, Irremediable Er Stress, Signal Transduction +11

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

Dan Han, Alana G. Lerner, Lieselotte Vande Walle et al. · Cell · 2009 · 798 citations · Full text

Transcriptional Regulation, Signal Transduction, Divergent Cell Fates +11

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

Jennifer L. Harris, Bradley J. Backes, Francesco Leonetti et al. · Proceedings of the National Academy of Sciences · 2000 · 539 citations · Full text

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

Rajarshi Ghosh, Likun Wang, Eric S. Wang et al. · Cell · 2014 · 473 citations · Full text

Reductive Stress, Allosteric Inhibition, Molecular Regulation +9

Fmoc-Based Synthesis of Peptide-^αThioesters:  Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation

Youngsook Shin, Katharine A. Winans, Bradley J. Backes et al. · Journal of the American Chemical Society · 1999 · 363 citations