Youngsook Shin

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 677 citations · Full text

Drug Target, Solid Tumors, Molecular Biology +20

Fmoc-Based Synthesis of Peptide-^αThioesters:  Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation

Youngsook Shin, Katharine A. Winans, Bradley J. Backes et al. · Journal of the American Chemical Society · 1999 · 363 citations

Discovery of <i>N</i>-(1-Acryloylazetidin-3-yl)-2-(1<i>H</i>-indol-1-yl)acetamides as Covalent Inhibitors of KRAS^G12C

Youngsook Shin, Joon Won Jeong, Ryan P. Wurz et al. · ACS Medicinal Chemistry Letters · 2019 · 101 citations · Full text

Discovery and in Vivo Evaluation of (<i>S</i>)-<i>N</i>-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9<i>H</i>-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Timothy D. Cushing, Xiaolin Hao, Youngsook Shin et al. · Journal of Medicinal Chemistry · 2014 · 84 citations

Pharmaceutical Science, Immune Regulation, Immunology +23

Synthesis of Oxime-Linked Mucin Mimics Containing the Tumor-Related T_N and Sialyl T_N Antigens

Lisa A. Marcaurelle, Youngsook Shin, Scarlett Goon et al. · Organic Letters · 2001 · 77 citations · Full text

Bioorganic Chemistry, Multiple Ketone, Molecular Biology +21