Brian A. Lanman

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon, Karen Rex, Anne Y. Saiki et al. · Nature · 2019 · 2.3K citations

Medicine, Oncology, Pharmacology +14

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen et al. · Journal of Medicinal Chemistry · 2019 · 722 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Discovery of <i>N</i>-(1-Acryloylazetidin-3-yl)-2-(1<i>H</i>-indol-1-yl)acetamides as Covalent Inhibitors of KRAS^G12C

Youngsook Shin, Joon Won Jeong, Ryan P. Wurz et al. · ACS Medicinal Chemistry Letters · 2019 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess

Andrew G. Myers, Boyu Zhong, Mohammad Movassaghi et al. · Tetrahedron Letters · 2000 · 101 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

On the Structure of Palau'amine:  Evidence for the Revised Relative Configuration from Chemical Synthesis

Brian A. Lanman, Larry E. Overman, Ralph Paulini et al. · Journal of the American Chemical Society · 2007 · 74 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +11