The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon, Karen Rex, Anne Y. Saiki, +31

Nature

Cancer ImmunosurveillanceClinical KrasImmunologyTumor ImmunityImmune Checkpoint Inhibitor +3

KRAS ^G12C Inhibition with Sotorasib in Advanced Solid Tumors

David S. Hong, Marwan Fakih, John H. Strickler, +31

New England Journal of Medicine

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen, +41

Journal of Medicinal Chemistry

Drug TargetSolid TumorsMolecular BiologyCryptic PocketChemical Biology +18

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P. Brown, Brian Belmontes, +35

Cancer Discovery

Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Daqing Sun, Zhihong Li, Yosup Rew, +46

Journal of Medicinal Chemistry

AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer

Michael J. Giffin, Keegan S. Cooke, Edward K. Lobenhofer, +20

Clinical Cancer Research

Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis

Jude Canon, Martine P. Roudier, R.J. Bryant, +4

Clinical & Experimental Metastasis

Breast OncologyMedicineMouse ModelCancer BiologyBreast Cancer +7

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

Yosup Rew, Daqing Sun, Felix González-López de Turiso, +32

Journal of Medicinal Chemistry

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents

Jude Canon, Tao Osgood, Steven H. Olson, +14

Molecular Cancer Therapeutics

Amg 232Tumor BiologyP53-inducing Cytotoxic AgentsMdm2-p53 InteractionMedicine +11

Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell–recruiting Antibody Optimized for Cytotoxicity and Cytokine Release

Christina L. Zuch de Zafra, Flordeliza Fajardo, Wendy Zhong, +13

Clinical Cancer Research