The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon, Karen Rex, Anne Y. Saiki, +31

Nature

Cancer ImmunosurveillanceClinical KrasImmunologyTumor ImmunityImmune Checkpoint Inhibitor +3

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors

Brian A. Lanman, Jennifer R. Allen, John G. Allen, +41

Journal of Medicinal Chemistry

Drug TargetSolid TumorsMolecular BiologyCryptic PocketChemical Biology +18

Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality.

Catherine L. Farrell, J. V. Bready, Karen Rex, +15

PubMed

Radiation EffectImmunologyImmune RegulationPathologyCell Death +17

Fully Human Monoclonal Antibodies to Hepatocyte Growth Factor with Therapeutic Potential against Hepatocyte Growth Factor/c-Met–Dependent Human Tumors

Teresa L. Burgess, Angela Coxon, Susanne Meyer, +17

Cancer Research

Influences of neurotrophins on mammalian motoneurons <i>in vivo</i>

Yan Qiao, Jeffrey L. Elliott, Christine R. Matheson, +5

Journal of Neurobiology

Synaptic TransmissionSpinal MotoneuronsRetrograde TransportNeurotransmissionCellular Neurobiology +17

Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody

Angela Coxon, James Bready, Hosung Min, +31

Molecular Cancer Therapeutics

AngiogenesisContext-dependent RoleAng1 NeutralizationTumor GrowthImmunology +11

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Brian K. Albrecht, Jean-Christophe Harmange, David Bauer, +27

Journal of Medicinal Chemistry

Combinatorial ChemistryChemoprevention StrategySelective InhibitorsCancer BiologyPharmaceutical Chemistry +20

c-Met Inhibitors with Novel Binding Mode Show Activity against Several Hereditary Papillary Renal Cell Carcinoma-related Mutations

Steven F. Bellon, Paula Kaplan‐Lefko, Yajing Yang, +13

Journal of Biological Chemistry

AMG 102, A Fully Human Anti-Hepatocyte Growth Factor/Scatter Factor Neutralizing Antibody, Enhances the Efficacy of Temozolomide or Docetaxel in U-87 MG Cells and Xenografts

H. Toni Jun, Jan Sun, Karen Rex, +4

Clinical Cancer Research

Structure-Based Design of Novel Class II c-Met Inhibitors: 1. Identification of Pyrazolone-Based Derivatives

Mark H. Norman, Longbin Liu, Matthew Lee, +8

Journal of Medicinal Chemistry

Combinatorial ChemistryClass IiDrug TargetPharmaceutical ChemistryClass Ii Inhibitors +16