Guy S. Salvesen

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Life Sciences, Genetics, Neurology +17

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee et al. · Nature · 2015 · 3.7K citations

Life Sciences, Cell Biology, Immunology +13

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Michael H. Cardone, Natalie Roy, Henning R. Stennicke et al. · Science · 1998 · 3.1K citations

Life Sciences, Biochemistry, Molecular Biology +17

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Muneesh Tewari, Long T. Quan, Karen O’Rourke et al. · Cell · 1995 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Warren J. Strittmatter, Karl H. Weisgraber, Daoyuan Huang et al. · Proceedings of the National Academy of Sciences · 1993 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +16