Concepedia

Protease Active Sites

Protease Active Sites is a structural motif in enzyme architecture that comprises the specific arrangement of amino acid residues responsible for substrate binding and catalytic activity in proteolytic enzymes, distinguishing it from other functional domains by its direct involvement in peptide bond hydrolysis.

1.7K

Publications

113.4K

Citations

6.8K

Authors

1.4K

Institutions

Publications per year

2017–2026

157

Variants

Proteolytic Active Sites

Parents

Publications

1.7K

On the size of the active site in proteases. I. Papain

Israël Schechter, Arieh Berger · Biochemical and Biophysical Research Communications · 1967 · 5.2K citations

, , +9

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

Zhiyin Song, Hsiuchen Chen, Maja Fiket et al. · The Journal of Cell Biology · 2007 · 810 citations · Full text

, , +16

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski et al. · Proceedings of the National Academy of Sciences · 2003 · 758 citations

, , +16

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

Teresa Fernandes‐Alnemri, Robert C. Armstrong, Joseph Krebs et al. · Proceedings of the National Academy of Sciences · 1996 · 732 citations

, , +17

Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 Å Resolution

Maria Miller, Jens Schneider, Bangalore K. Sathyanarayana et al. · Science · 1989 · 687 citations

, , +15

1–5 of 1.7K

Authors

6.8K

  1. IT
    Irene T. Weber

    Georgia State University, United States

    22 publications · 1.3K citations

    19

    h-index

  2. CS
    Charles S. Craik

    University of California, San Francisco, United States

    19 publications · 1.8K citations

    18

    h-index

  3. MG
    M. Groll

    Technical University of Munich, Germany

    16 publications · 1.5K citations

    16

    h-index

  4. RH
    Robert Huber

    Max Planck Institute of Biochemistry, Germany

    15 publications · 1.6K citations

    15

    h-index

  5. AW
    Alexander Wlodawer

    Frederick National Laboratory for Cancer Research, United States

    15 publications · 1.7K citations

    14

    h-index

1–5 of 6.8K

Institutions

1.4K

  1. University of California, San Francisco

    San Francisco, United States

    36 h-index

    173 publications

    17.9K citations

  2. National Institutes of Health

    Bethesda, United States

    31 h-index

    130 publications

    10.2K citations

  3. Max Planck Institute of Biochemistry

    Martinsried, Germany

    30 h-index

    119 publications

    11.9K citations

  4. Harvard University

    Cambridge, United States

    27 h-index

    117 publications

    20.7K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    27 h-index

    85 publications

    5.6K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    26 h-index

    138 publications

    5.8K citations

  7. University of Alberta

    Edmonton, Canada

    21 h-index

    80 publications

    8.1K citations

  8. Washington University in St. Louis

    St Louis, United States

    19 h-index

    67 publications

    6.9K citations

1–8 of 1.4K

Venues

  1. Journal of Biological Chemistry

    JBC · 280 publications · 20.7K citations

    80

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 88 publications · 11.4K citations

    64

    h-index

  3. Biochemistry

    124 publications · 6.6K citations

    49

    h-index

  4. Journal of Molecular Biology

    JMB · 57 publications · 4.2K citations

    38

    h-index

  5. FEBS Letters

    54 publications · 2.7K citations

    33

    h-index

1–5