Oncogene · 2010 · 114 citations · 26 references
Life SciencesCancer BiologyOncologyApoptosisCell SignalingSignal TransductionApoptosis In CancerApoptosis ResistanceApoptotic SignalingCancer Cell SignalingOncogenic Signaling PathwaysRas Family OncogenesB-raf InhibitorsErk SignalingExtracellular Signal-regulated Kinase PathwayExtracellular Signal-regulated Kinase SignalingMek SignalingRaf SignalingRaf-mek-erk Signaling
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Mutations of the BRAF gene in human cancer
Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations
Medicine, Cancer Biology, Oncology +15
Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
Sonja J. Heidorn, Carla Milagre, Steven R. Whittaker et al. · Cell · 2010 · 1.5K citations · Full text