Fred M. Kaplan

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Alessandra Rustighi, Luca Tiberi, Alessia Soldano et al. · Nature Cell Biology · 2009 · 169 citations · Full text

Tumor Biology, Prolyl-isomerase Pin1, Notch1 Target +11

Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells

Fred M. Kaplan, Yongping Shao, Melanie M. Mayberry et al. · Oncogene · 2010 · 113 citations · Full text

Medicine, Receptor Tyrosine Kinase, Apoptosis +9

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

Brian Tomkowicz, Eileen S. Walsh, Adam Cotty et al. · PLoS ONE · 2015 · 75 citations · Full text

Nfat Signaling Pathway, Immunology, Immune Regulation +25

SHOC2 and CRAF Mediate ERK1/2 Reactivation in Mutant NRAS-mediated Resistance to RAF Inhibitor

Fred M. Kaplan, Curtis H. Kugel, Neda Dadpey et al. · Journal of Biological Chemistry · 2012 · 65 citations · Full text

Molecular Biology, Cell Death, Cancer Biology +19

Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity

Prathibha Ranganathan, Rodrigo Vasquez‐Del Carpio, Fred M. Kaplan et al. · Journal of Biological Chemistry · 2011 · 45 citations · Full text

Molecular Regulation, Serine 1901, Molecular Biology +18