Concepedia

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics

Haiying Sun, Zaneta Nikolovska‐Coleska, Jianyong Chen, Chao‐Yie Yang, York Tomita, Hongguang Pan, Yoshiko Yoshioka, Krzysztof Krajewski, Peter P. Roller, Shaomeng Wang

Bioorganic & Medicinal Chemistry Letters · 2004 · 43 citations · 16 references

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References

16

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Chunying Du, Min Fang, Yucheng Li et al. · Cell · 2000 · 3.5K citations · Full text

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Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Anne M. Verhagen, Paul G. Ekert, Miha Pakusch et al. · Cell · 2000 · 2.3K citations · Full text

, , +14

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

Srinivasa M. Srinivasula, R.P. Hegde, Ayman Saleh et al. · Nature · 2001 · 1K citations

, , +14

Structural basis of IAP recognition by Smac/DIABLO

Geng Wu, Jijie Chai, Tomeka Suber et al. · Nature · 2000 · 856 citations

, , +12

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

Simone Fulda, Wolfgang Wick, Michael Weller et al. · Nature Medicine · 2002 · 741 citations

, , +14