Concepedia

Structure-based Peptidomimetics

Structure-Based Peptidomimetics is a peptidomimetic design approach that belongs to the class of structure-guided drug design methods and is distinguished by its reliance on the three-dimensional structural information of a target protein–peptide interaction to guide the rational construction of non-peptidal molecules that mimic the bioactive conformation and key intermolecular interactions of the native peptide.

969

Publications

40.7K

Citations

5.1K

Authors

1K

Institutions

Publications per year

2017–2026

191

Parents

Publications

969

β-Peptidic Peptidomimetics

Dieter Seebàch, James Gardiner · Accounts of Chemical Research · 2008 · 700 citations

, , +15

Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics

Stephen Hanessian, Grant McNaughton‐Smith, Henry‐Georges Lombart et al. · Tetrahedron · 1997 · 630 citations

, , +16

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

Linlin Zhang, Daizong Lin, Yuri Kusov et al. · Journal of Medicinal Chemistry · 2020 · 606 citations · Full text

, , +17

Design of peptides, proteins, and peptidomimetics in chi space

Victor J. Hruby, Guigen Li, Carrie Haskell‐Luevano et al. · Biopolymers · 1997 · 354 citations

, , +17

β-Hairpin Peptidomimetics: Design, Structures and Biological Activities

John A. Robinson · Accounts of Chemical Research · 2008 · 318 citations

, , +15

1–5 of 969

Authors

5.1K

  1. RH
    Ralph Hirschmann

    University of Pennsylvania, United States

    14 publications · 1.1K citations

    14

    h-index

  2. AD
    Andrew D. Hamilton

    Yale University, United States

    15 publications · 1.4K citations

    13

    h-index

  3. AB
    Amos B. Smith

    University of Pennsylvania, United States

    13 publications · 792 citations

    13

    h-index

  4. TS
    Tanja Schirmeister

    Johannes Gutenberg University Mainz, Germany

    12 publications · 587 citations

    12

    h-index

  5. RL
    Rodney L. Johnson

    University of Minnesota, United States

    11 publications · 438 citations

    11

    h-index

1–5 of 5.1K

Institutions

1K

  1. Centre National de la Recherche Scientifique

    Paris, France

    21 h-index

    202 publications

    8K citations

  2. University of Milan

    Milan, Italy

    20 h-index

    117 publications

    3.8K citations

  3. University of South Florida

    Tampa, United States

    18 h-index

    98 publications

    8.3K citations

  4. University of Pennsylvania

    Philadelphia, United States

    16 h-index

    99 publications

    6.6K citations

  5. University of Minnesota

    Minneapolis, United States

    16 h-index

    81 publications

    3.7K citations

  6. Yale University

    New Haven, United States

    14 h-index

    61 publications

    6.5K citations

  7. University of Copenhagen

    Copenhagen, Denmark

    13 h-index

    64 publications

    1.9K citations

  8. University of Michigan

    Ann Arbor, United States

    12 h-index

    92 publications

    8.4K citations

1–8 of 1K

Venues

  1. Journal of Medicinal Chemistry

    115 publications · 6.3K citations

    47

    h-index

  2. Journal of the American Chemical Society

    JACS · 44 publications · 3.9K citations

    36

    h-index

  3. The Journal of Organic Chemistry

    JOC · 53 publications · 1.7K citations

    27

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    70 publications · 1.9K citations

    26

    h-index

  5. Organic Letters

    OL · 34 publications · 1.2K citations

    24

    h-index

1–5