Chao‐Yie Yang

The PDBbind Database:  Methodologies and Updates

Renxiao Wang, Xueliang Fang, Yipin Lu et al. · Journal of Medicinal Chemistry · 2005 · 946 citations

Life Sciences, Biochemistry, Bioinformatics +15

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

Longchuan Bai, Haibin Zhou, Renqi Xu et al. · Cancer Cell · 2019 · 618 citations · Full text

Medicine, Molecular Biology, Oncology +7

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

Xin Han, Chao Wang, Chong Qin et al. · Journal of Medicinal Chemistry · 2019 · 381 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Bing Zhou, Jiantao Hu, Fuming Xu et al. · Journal of Medicinal Chemistry · 2017 · 361 citations · Full text

Medicine, Medicinal Chemistry, Oncology +13

Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression

Yangbing Li, Jiuling Yang, Angelo Aguilar et al. · Journal of Medicinal Chemistry · 2018 · 299 citations · Full text

Medicine, Oncology, Pharmacology +10