Chao Wang

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

Xiaoguang Liu, Litong Nie, Yilei Zhang et al. · Nature Cell Biology · 2023 · 1K citations · Full text

Actin Cytoskeleton Vulnerability, Protein Secretion, Natural Sciences +9

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Yilei Zhang, Robert V. Swanda, Litong Nie et al. · Nature Communications · 2021 · 669 citations · Full text

Glutathione Peroxidase 4, Lipid Peroxidation, Molecular Biology +20

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

Xin Han, Chao Wang, Chong Qin et al. · Journal of Medicinal Chemistry · 2019 · 371 citations · Full text

Androgen Receptor, Urology, Drug Targeting +11

ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

Xu Feng, Anthony Tubbs, Chunchao Zhang et al. · The EMBO Journal · 2020 · 135 citations · Full text

Transcriptional Regulation, Radiation Medicine, Signal Transduction +12

Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

Chao Wang, Gang Wang, Xu Feng et al. · Oncogene · 2018 · 133 citations

Off-target Effect, Genetics, Molecular Biology +8