Longchuan Bai

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

Longchuan Bai, Haibin Zhou, Renqi Xu et al. · Cancer Cell · 2019 · 575 citations · Full text

Cancer Research, Medicine, Small Molecules +9

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Bing Zhou, Jiantao Hu, Fuming Xu et al. · Journal of Medicinal Chemistry · 2017 · 351 citations · Full text

SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression

Shaomeng Wang, Wei Sun, Yujun Zhao et al. · Cancer Research · 2014 · 335 citations · Full text

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Chong Qin, Yang Hu, Bing Zhou et al. · Journal of Medicinal Chemistry · 2018 · 258 citations · Full text

Molecular Biology, Bet Proteins, Bet Inhibitors +22

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

Haibin Zhou, Longchuan Bai, Renqi Xu et al. · Journal of Medicinal Chemistry · 2019 · 201 citations · Full text

Stat3 Sh2 Domain, Protein Assembly, Molecular Biology +22