Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Anne M. Verhagen, Paul G. Ekert, Miha Pakusch, +6

Cell

Protein FunctionAutoimmune DiseaseApoptosisImmunologyCell Death +7

Programmed Anuclear Cell Death Delimits Platelet Life Span

Kylie D. Mason, Marina R. Carpinelli, Jamie I. Fletcher, +9

Cell

ThrombopoiesisBlood PlateletHematologyBlood CellCell Death +2

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, +22

Journal of Clinical Investigation

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

Christopher N Hahn, Chan‐Eng Chong, Catherine Carmichael, +25

Nature Genetics

Hematological MalignancySomatic VariantGenetic DisorderAcute Myeloid LeukemiaGenetics +6

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A. Rickard, Joanne A. O’Donnell, Joseph M. Evans, +27

Cell

InflammationCytokineReceptor Tyrosine KinaseImmunologyHematology +5

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Vanessa S. Marsden, Liam O’Connor, Lorraine A. O’Reilly, +13

Nature

MitophagyBcl-2-regulated Caspase ActivationSignal TransductionMedicineApoptosis +7

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

Anne M. Verhagen, John Silke, Paul G. Ekert, +10

Journal of Biological Chemistry

A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders

Zornitza Stark, Tiong Yang Tan, Belinda Chong, +27

Genetics in Medicine

Mendelian DisorderGenetic DisorderWhole-exome SequencingGeneticsMedicine +10

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Marie Wong, Chelsea Mayoh, Loretta M. S. Lau, +45

Nature Medicine

Functional GenomicsHigh-risk Pediatric CancerMedicineEpigenetic ChangeEpigenomics +7

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

Thomas Kaufmann, Lin Tai, Paul G. Ekert, +6

Cell

Genome InstabilityProtein FunctionNatural SciencesApoptosisMolecular Biology +7