ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll, Bettina Proneth, Yulia Y. Tyurina, +18

Nature Chemical Biology

Proteinlipid InteractionBiochemistryNatural SciencesFerroptosis SensitivityLipid Movement +2

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll, Florêncio Porto Freitas, Ron Shah, +29

Nature

Redox SignalingSignal TransductionBiochemistryMedicineNatural Sciences +5

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Irina Ingold, Carsten Berndt, Sabine Schmitt, +21

Cell

BiochemistrySelenium DeficiencySelenium UtilizationReactive Oxygen SpecieMedicine +4

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Sung Eun Kim, Li Zhang, Kai Ma, +15

Nature Nanotechnology

NanoparticlesNanomedicineUltrasmall NanoparticlesEngineeringTumour Growth +11

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, +22

Journal of Clinical Investigation

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Wulf Tonnus, Claudia Meyer, Christian Steinebach, +29

Nature Communications

Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van Coillie, Emily Van San, Ines Goetschalckx, +26

Nature Communications

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

Michèle Telorack, Michaël Meyer, Irina Ingold, +3

PLoS Genetics

Lipid PeroxidationImmunologyGlutamate Cysteine LigaseCell DeathEfficient Wound Healing +15

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

Eliška Holzerová, Katharina Danhauser, Tobias B. Haack, +15

Brain

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

Irina Ingold, Michaela Aichler, Elena Yefremova, +10

Journal of Biological Chemistry

Glutathione Peroxidase 4FertilityGeneticsReproductive BiologyRedox Biology +17