Cell · 2015 · 265 citations · 31 references
Life SciencesGeneticsMolecular BiologyGenome EditingGenome EngineeringStructural BiologyCrispr-based EngineeringCrispr-cas SystemsGenetic CodeGuide Rna DesignCrispr-based Genome EngineeringPam Sequence RecognitionPam Site DiscoveryPam Specificity EngineeringProtospacer Adjacent Motif RecognitionSpacer Sequence Design
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CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau et al. · Science · 2007 · 6.3K citations
Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
Stan J. J. Brouns, Matthijs M. Jore, Magnus Lundgren et al. · Science · 2008 · 2.6K citations · Full text
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
Josiane E. Garneau, Marie-Ève Dupuis, Manuela Villion et al. · Nature · 2010 · 2.3K citations