The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a

Liang Liu, Xueyan Li, Jun Ma, +6

Cell

Rna-guided Rna CleavageNatural SciencesRna Structure PredictionRna BiologyMolecular Biology +4

Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities

Liang Liu, Xueyan Li, Jiuyu Wang, +6

Cell

BiochemistryNatural SciencesRna Structure PredictionC2c2 Rnase ActivitiesRna Biology +3

Structure-based cleavage mechanism of <i>Thermus thermophilus</i> Argonaute DNA guide strand-mediated DNA target cleavage

Gang Sheng, Hongtu Zhao, Jiuyu Wang, +6

Proceedings of the National Academy of Sciences

Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems

Jiuyu Wang, Jiazhi Li, Hongtu Zhao, +4

Cell

EngineeringCrispr-cas SystemsMechanistic BasisGenetic EngineeringMolecular Biology +8

Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli

Hongtu Zhao, Gang Sheng, Jiuyu Wang, +5

Nature

Crystal StructureStructural BioinformaticsProtein X-ray CrystallographyEscherichia ColiMolecular Biology +3

C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism

Liang Liu, Peng Chen, Min Wang, +4

Molecular Cell

Natural SciencesC2c1-sgrna Complex StructureRna BiologyMolecular BiologyGene Expression

Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

Lilan You, Jun Ma, Jiuyu Wang, +7

Cell

Co-transcriptional InterferenceChromatinTranscriptional RegulationChromatin StructureStructure Studies +10

Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites

Maolu Yin, Jiuyu Wang, Min Wang, +4

Cell Research

Sequence MotifDna SequencingFunctional GenomicsMedicineGenetics +12

Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States

Wei Sun, Jing Yang, Zhi Cheng, +14

Molecular Cell

MedicineMolecular BiologyGene EditingGenome EditingMicrobiology +5

Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2

Xue Huang, Wei Sun, Zhi Cheng, +6

Nature Communications