Spacer Sequence Design is a methodological framework within guide RNA design that specifies the selection and optimization of the nucleotide sequence directly responsible for target recognition, distinguishing it from associated scaffold or delivery considerations by focusing exclusively on the genomic targeting specificity and efficiency of the CRISPR system.
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Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems
Jiuyu Wang, Jiazhi Li, Hongtu Zhao et al. · Cell · 2015 · 265 citations · Full text
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Delft University of Technology
Delft, The Netherlands
3 h-index
14 publications
860 citations
University of California, Berkeley
Berkeley, United States
3 h-index
11 publications
3.1K citations
Wageningen University & Research
Wageningen, The Netherlands
2 h-index
7 publications
686 citations
Eötvös Loránd University
Budapest, Hungary
2 h-index
5 publications
380 citations
Innovative Genomics Institute
Berkeley, United States
2 h-index
5 publications
274 citations
University of Szeged
Szeged, Hungary
2 h-index
4 publications
161 citations
Salk Institute for Biological Studies
La Jolla, United States
2 h-index
5 publications
228 citations
University of Bath
Bath, United Kingdom
2 h-index
8 publications
140 citations
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- Nucleic Acids Research
4 publications · 284 citations
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2 publications · 132 citations
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- Methods in molecular biology
Book series · 1 publications · 28 citations
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- Frontiers in Plant Science
1 publications · 20 citations
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- PLoS ONE
1 publications · 52 citations
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