Wen Y. Wu

Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju et al. · Nature Biotechnology · 2016 · 953 citations · Full text

Gene Therapies, Systems Biology, Engineering +10

Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a

Sjoerd C.A. Creutzburg, Wen Y. Wu, Prarthana Mohanraju et al. · Nucleic Acids Research · 2020 · 102 citations · Full text

Engineering, Structural Bioinformatics, Biomolecular Structure Prediction +15

Cryo-EM structure of the transposon-associated TnpB enzyme

Ryoya Nakagawa, Hisato Hirano, Satoshi N. Omura et al. · Nature · 2023 · 92 citations · Full text

The miniature CRISPR-Cas12m effector binds DNA to block transcription

Wen Y. Wu, Prarthana Mohanraju, Chunyu Liao et al. · Molecular Cell · 2022 · 90 citations · Full text

Transcriptional Regulation, Natural Sciences, Molecular Biology +9

Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme

Satoshi N. Omura, Ryoya Nakagawa, Christian Südfeld et al. · Nature Structural & Molecular Biology · 2023 · 27 citations · Full text