Publication | Open Access

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

Medicinal ChemistryEfficacious Mglu5BiochemistryG Protein-coupled ReceptorMedicineNatural SciencesFunctional SelectivityMechanism Of ActionPharmacological AgentNeuropharmacologyPharmacotherapyNegative Allosteric ModulatorPharmacologyDrug Discovery