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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

Junliang Hao, Veronique Dehlinger, Adam M. Fivush, Hélène Rudyk, Thomas C. Britton, Sean P. Hollinshead, Benjamin Vokits, Barry P. Clark, Steven S. Henry, Steven M. Massey,

Bioorganic & Medicinal Chemistry Letters · 2013 · 11 citations · 20 references

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20

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

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Pd/P(<i>t</i>-Bu)<sub>3</sub>:  A Mild and General Catalyst for Stille Reactions of Aryl Chlorides and Aryl Bromides

Adam F. Littke, Lothar Schwarz, Gregory C. Fu · Journal of the American Chemical Society · 2002 · 447 citations

, , +11

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

, , +16

Efficacy of Duloxetine, a Potent and Balanced Serotonin-Norepinephrine Reuptake Inhibitor in Persistent Pain Models in Rats

Smriti Iyengar, Amy A. Webster, Susan K. Hemrick-Luecke et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 293 citations

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Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

Will Spooren, A. Vassout, H.C. Neijt et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 266 citations

, , +15