2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr, +15

Neuropharmacology

BiochemistryFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +5

CPCCOEt, a Noncompetitive Metabotropic Glutamate Receptor 1 Antagonist, Inhibits Receptor Signaling Without Affecting Glutamate Binding

Stephane Litschig, F. Gasparini, D Rueegg, +6

Molecular Pharmacology

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

Adriana Pagano, Doris Rüegg, Stephane Litschig, +12

Journal of Biological Chemistry

A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters<i>in vivo</i>

Kayo Mitsukawa, Rina Yamamoto, Silvio Ofner, +10

Proceedings of the National Academy of Sciences

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function

Katherine Walker, M. Bowes, Moh Panesar, +13

Neuropharmacology

Pain MedicineMedicineNeuropathic PainMolecular PainNeuropharmacology +5

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Michael Bidinosti, Paolo Botta, Sebastian Krüttner, +17

Science

Synaptic TransmissionNeurochemical BiomarkersRapamycin Complex 1Synaptic SignalingSocial Sciences +23

[3H]-M-MPEP, a Potent, Subtype-Selective Radioligand for the Metabotropic Glutamate Receptor Subtype 5

F. Gasparini, Hendrik Andres, Peter J. Flor, +10

Bioorganic & Medicinal Chemistry Letters

BiochemistryG Protein-coupled ReceptorMedicineFunctional SelectivityReceptor (Biochemistry) +7

Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression

Catia C. Proenca, Natacha Stoehr, Mario Bernhard, +9

PLoS ONE

Cell AutophagyNeurodegenerative DiseasesMitophagyDisease ProgressionMtor Inhibition +10

Chiral Resolution, Pharmacological Characterization, and Receptor Docking of the Noncompetitive mGlu1 Receptor Antagonist (±)-2-Hydroxyimino- 1a,2-dihydro-1<i>H</i>-7-oxacyclopropa[<i>b</i>]naphthalene-7a-carboxylic Acid Ethyl Ester

David E. Ott, Philipp Floersheim, Werner Inderbitzin, +8

Journal of Medicinal Chemistry

Chiral ResolutionPharmacological CharacterizationBioorganic ChemistryReceptor AntagonistsOptical Isomers +18