Silvio Ofner

A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters <i>in vivo</i>

Kayo Mitsukawa, Rina Yamamoto, Silvio Ofner et al. · Proceedings of the National Academy of Sciences · 2005 · 235 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia

Claudia Betschart, Samuel Hintermann, Dirk Behnke et al. · Journal of Medicinal Chemistry · 2013 · 103 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior

Christine E. Gee, Daniel Peterlik, Christoph Neuhäuser et al. · Journal of Biological Chemistry · 2014 · 75 citations · Full text

Life Sciences, Neuroscience, Pharmacology +13

AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization

Ivo Vranesic, Silvio Ofner, Peter J. Flor et al. · Bioorganic & Medicinal Chemistry · 2014 · 55 citations

Medicine, Medicinal Chemistry, Pharmacology +6

NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats

A. Vassout, Siem J. Veenstra, Kathleen Hauser et al. · Regulatory Peptides · 2000 · 54 citations

Medicine, Neuroscience, Pharmacology +5