AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Epigenetic Modification of the <i>FMR1</i> Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

Sébastien Jacquemont, Aurore Curie, Vincent des Portes et al. · Science Translational Medicine · 2011 · 611 citations

Life Sciences, Molecular Biology, Neuroscience +17

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

A.S. Dore, Krzysztof Okrasa, Jayesh C. Patel et al. · Nature · 2014 · 411 citations

Life Sciences, Molecular Biology, Neuroscience +12

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

CPCCOEt, a Noncompetitive Metabotropic Glutamate Receptor 1 Antagonist, Inhibits Receptor Signaling Without Affecting Glutamate Binding

Stephane Litschig, F. Gasparini, D Rueegg et al. · Molecular Pharmacology · 1999 · 343 citations

Life Sciences, Neuroscience, Pharmacology +16