2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr, +15

Neuropharmacology

BiochemistryFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +5

CPCCOEt, a Noncompetitive Metabotropic Glutamate Receptor 1 Antagonist, Inhibits Receptor Signaling Without Affecting Glutamate Binding

Stephane Litschig, F. Gasparini, D Rueegg, +6

Molecular Pharmacology

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

Adriana Pagano, Doris Rüegg, Stephane Litschig, +12

Journal of Biological Chemistry

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function

Katherine Walker, M. Bowes, Moh Panesar, +13

Neuropharmacology

Pain MedicineMedicineNeuropathic PainMolecular PainNeuropharmacology +5

Responses to Metabotropic Glutamate Receptor Activation in Cerebellar Purkinje Cells: Induction of an Inward Current

C. Staub, Ivo Vranesic, Thomas Knöpfel

European Journal of Neuroscience

Cerebellar Purkinje CellsSynaptic TransmissionNeurotransmitterNeurotransmissionSynaptic Signaling +17

Climbing Fibre Responses in Olivo‐cerebellar Slice Cultures. II. Dynamics of Cytosolic Calcium in Purkinje Cells

Thomas Knöpfel, Ivo Vranesic, C. Staub, +1

European Journal of Neuroscience

Fibre ResponsesNeurotransmissionCellular NeurobiologyCellular PhysiologyHyperpolarization (Biology) +16

The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in l-Dopa-treated parkinsonian monkeys

Laurent Grégoire, Nicolas Morin, Bazoumana Ouattara, +7

Parkinsonism & Related Disorders

NeurophysiologyMedicineNeurotransmitterNeuropharmacologyNeuroprotection +8

Trans-ACPD-induced Ca2+ signals in cerebellar Purkinje cells

Ivo Vranesic, Andrew Batchelor, B.H. Gähwiler, +3

Neuroreport

Metabotropic glutamate receptor type 5 in levodopa-induced motor complications

Bazoumana Ouattara, Laurent Grégoire, Marc Morissette, +9

Neurobiology of Aging

Levodopa-induced Motor ComplicationsNeurological DisorderNeuropharmacologyMotor DisorderNeurology +2

Muscarinic and beta-adrenergic depression of the slow Ca2(+)-activated potassium conductance in hippocampal CA3 pyramidal cells is not mediated by a reduction of depolarization-induced cytosolic Ca2+ transients.

Thomas Knöpfel, Ivo Vranesic, B.H. Gähwiler, +1

Proceedings of the National Academy of Sciences

Potassium ConductanceSynaptic TransmissionNeurotransmitterNeurotransmissionCa2+ Dynamics +18