Barry P. Clark

(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors

Barry P. Clark, Stephen Baker, John Goldsworthy et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 134 citations

Life Sciences, Neuroscience, Pharmacology +12

Neuroprotective Actions of Novel and Potent Ligands of Group I and Group II Metabotropic Glutamate Receptors

Anne Kingston, Michael J. O’Neill, A. Bond et al. · Annals of the New York Academy of Sciences · 1999 · 62 citations

Medicine, Neuroscience, Pharmacology +15

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1<i>S</i>,2<i>S</i>,5<i>R</i>,6<i>S</i>-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 61 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Stereoselective Synthesis of β-(Hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones

David M. Hodgson, Eric P. A. Talbot, Barry P. Clark · Organic Letters · 2011 · 60 citations

Natural Sciences, Chemistry, Organic Chemistry +4

Synthesis and Pharmacological Characterization of <i>C</i>4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1<i>R</i>,2<i>S</i>,4<i>R</i>,5<i>R</i>,6<i>R</i>)-2-Amino-4-(1<i>H</i>-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu₂ Receptor Agonist

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 57 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10