Lorena Taboada

In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat

Gary Gilmour, Lisa M. Broad, Keith A. Wafford et al. · Neuropharmacology · 2012 · 61 citations

Molecular Pharmacology, Sleep, Vitro Characterisation +15

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1<i>S</i>,2<i>S</i>,5<i>R</i>,6<i>S</i>-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 59 citations

Pharmacological Characterization, Pharmacotherapy, Experimental Pharmacology +18

Synthesis and Pharmacological Characterization of <i>C</i>4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1<i>R</i>,2<i>S</i>,4<i>R</i>,5<i>R</i>,6<i>R</i>)-2-Amino-4-(1<i>H</i>-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu₂ Receptor Agonist

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 56 citations · Full text

Pharmacological Characterization, Immunology, Pharmacotherapy +20

One-pot full peptide deprotection in Fmoc-based solid-phase peptide synthesis: methionine sulfoxide reduction with Bu4NBr

Lorena Taboada, Ernesto Nicolás, Ernest Giralt · Tetrahedron Letters · 2001 · 21 citations

Biochemistry, Peptide Engineering, Peptide Library +7

Pyrazine-based Syk kinase inhibitors

Pilar Forns, Cristina Esteve, Lorena Taboada et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 17 citations · Full text

Medicinal Chemistry, Medicine, Rational Drug Design +5