Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey, +12

Journal of Medicinal Chemistry

Pharmacological CharacterizationActive Group 2Psychotropic MedicationPharmacotherapyChemical Biology +14

Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740):  Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors

James A. Monn, Matthew J. Valli, Steven M. Massey, +14

Journal of Medicinal Chemistry

Active AgonistsMglu ReceptorsPharmacotherapyChemical BiologyPharmaceutical Chemistry +14

Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate:  Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors

James A. Monn, Steven M. Massey, Matthew J. Valli, +11

Journal of Medicinal Chemistry

S-oxidized VariantsPharmacotherapyChemical BiologyTyrosine Residue Y236Molecular Pharmacology +16

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1<i>S</i>,3<i>R</i>)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Junliang Hao, James P. Beck, John M. Schaus, +37

Journal of Medicinal Chemistry

Pharmacological CharacterizationDrug TargetPharmacotherapyExperimental PharmacologyPharmaceutical Chemistry +19

Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors:  Identification of a Subtype Selective mGlu2 Receptor Agonist

Carmen Domínguez, Lourdes Prieto, Matthew J. Valli, +8

Journal of Medicinal Chemistry

Mglu2/3 Receptor AntagonistMethyl SubstitutionMetabotropic Glutamate ReceptorsMolecular PhysiologyDetermines Functional Activity +12

A directed metalation of N-tert-butyl-N-methyl-2-methoxybenzamide. Short syntheses of 2-methoxy-6-methylbenzoic acid and lunularic acid

David B. Reitz, Steven M. Massey

The Journal of Organic Chemistry

Chemical EngineeringLunularic AcidEngineeringCross-coupling ReactionDerivative (Chemistry) +11

Synthesis and Pharmacological Characterization of C4_β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1<i>S,</i>2<i>S,</i>4<i>S,</i>5<i>R,</i>6<i>S</i>)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu₃Receptor Agonist

James A. Monn, Steven S. Henry, Steven M. Massey, +22

Journal of Medicinal Chemistry

Synthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists

James A. Monn, Matthew J. Valli, Steven M. Massey, +14

Journal of Medicinal Chemistry

Pharmacological CharacterizationPharmacotherapyHeterocycle ChemistryExperimental PharmacologyPharmaceutical Chemistry +19

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

Junliang Hao, Veronique Dehlinger, Adam M. Fivush, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryEfficacious Mglu5BiochemistryG Protein-coupled ReceptorMedicine +9

Diode-pumped Nd:YAG and Nd:glass spinning-disk lasers

Steven M. Massey, Jason McKay, Timothy H. Russell, +3

Journal of the Optical Society of America B

Optical PumpingPhotonicsDiode-pumped NdEngineeringLaser Science +11