Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties

Mary M. Mader, Alfonso de Dios, Chuan Shih, +27

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +6

Dipeptides as Effective Prodrugs of the Unnatural Amino Acid (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740), a Selective Group II Metabotropic Glutamate Receptor Agonist

Ana B. Bueno, Iván Collado, Alfonso de Dios, +18

Journal of Medicinal Chemistry

Unnatural Amino AcidPharmacotherapyEffective ProdrugsDrug ResistanceN Dipeptide Derivative +15

Enantiospecific synthesis of (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid by a modified Corey-Link reaction

Carmen Domínguez, Jesús Ezquerra, Stephen Baker, +4

Tetrahedron Letters

EngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistryStereoselective Synthesis +7

Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors:  Identification of a Subtype Selective mGlu2 Receptor Agonist

Carmen Domínguez, Lourdes Prieto, Matthew J. Valli, +8

Journal of Medicinal Chemistry

Mglu2/3 Receptor AntagonistMethyl SubstitutionMetabotropic Glutamate ReceptorsMolecular PhysiologyDetermines Functional Activity +12

Asymmetric synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740)

Carmen Domínguez, Jesús Ezquerra, Lourdes Prieto, +2

Tetrahedron Asymmetry

Asymmetric SynthesisOrganic ChemistryChemistryAsymmetric CatalysisSynthetic Chemistry +1

4-Alkyl- and 4-Cinnamylglutamic Acid Analogues Are Potent GluR5 Kainate Receptor Agonists

Concepción Pedregal, Iván Collado, Ana Escribano, +10

Journal of Medicinal Chemistry

Medicinal ChemistryGlur5 Kainate ReceptorsBiochemistryFunctional SelectivityMedicine +12

A Short Asymmetric Synthesis of (+)-Nonactic Acid and (-)-8-epi-Nonactic Acid Induced by a Chiral Sulfoxide Group

Guy Solladié, Carmen Domínguez

The Journal of Organic Chemistry

Short Asymmetric SynthesisEngineeringChiral Sulfoxide GroupAltmetric Attention ScoreChemometrics +13

Late‐onset metachromatic leukodystrophy clinically presenting as isolated peripheral neuropathy: Compound heterozygosity for the IVS2+1G→a mutation and a newly identified missense mutation (Thr408Ile) in a Spanish family

Manuel Comabella, John S. Waye, N. Raguer, +6

Annals of Neurology

Stereoselective cyclopropanation of enones with ethyl dimethylsulfonium acetate bromide in the presence of DBU

Iván Collado, Carmen Domínguez, Jesús Ezquerra, +2

Tetrahedron Letters

EngineeringHeterocyclicStereoselective CyclopropanationOrganic ChemistryStereoselective Synthesis +4

1,3-Dipolar cycloadditions between nitrile oxides and substituted 7-oxabicyclo[2.2.1]heptenes

Odón Arjona, Carmen Domínguez, Roberto Fernández de la Pradilla, +3

The Journal of Organic Chemistry

HeterocyclicChemical AnalysisAltmetric Attention ScoreNitrile Oxides1,3-Dipolar Cycloadditions +5