Carmen Domínguez

Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties

Mary M. Mader, Alfonso de Dios, Chuan Shih et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 114 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +8

Dipeptides as Effective Prodrugs of the Unnatural Amino Acid (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740), a Selective Group II Metabotropic Glutamate Receptor Agonist

Ana B. Bueno, Iván Collado, Alfonso de Dios et al. · Journal of Medicinal Chemistry · 2005 · 65 citations · Full text

Unnatural Amino Acid, Pharmacotherapy, Effective Prodrugs +17

Enantiospecific synthesis of (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid by a modified Corey-Link reaction

Carmen Domínguez, Jesús Ezquerra, Stephen Baker et al. · Tetrahedron Letters · 1998 · 54 citations

Engineering, Natural Sciences, Diversity-oriented Synthesis +9

Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors:  Identification of a Subtype Selective mGlu2 Receptor Agonist

Carmen Domínguez, Lourdes Prieto, Matthew J. Valli et al. · Journal of Medicinal Chemistry · 2005 · 53 citations · Full text

Mglu2/3 Receptor Antagonist, Methyl Substitution, Metabotropic Glutamate Receptors +14

Asymmetric synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740)

Carmen Domínguez, Jesús Ezquerra, Lourdes Prieto et al. · Tetrahedron Asymmetry · 1997 · 41 citations

Asymmetric Synthesis, Organic Chemistry, Chemistry +3