Chuan Shih

A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase

Edward C. Taylor, Dietmar Kuhnt, Chuan Shih et al. · Journal of Medicinal Chemistry · 1992 · 252 citations · Full text

Life Sciences, Chemistry, Pharmacology +10

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

S. Betty Yan, Victoria L. Peek, Rose T. Ajamie et al. · Investigational New Drugs · 2012 · 161 citations · Full text

Medicine, Oncology, Pharmacology +17

Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

Chuan Shih, Lillian L. Habeck, Laurane G. Mendelsohn et al. · Advances in Enzyme Regulation · 1998 · 144 citations

Life Sciences, Biochemistry, Pharmacology +12

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

Yi‐Hui Peng, Shau‐Hua Ueng, Chen‐Tso Tseng et al. · Journal of Medicinal Chemistry · 2015 · 136 citations · Full text

Pharmacy, Chemical Biology, Medicinal Chemistry +16

Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

Bryan H. Norman, Chuan Shih, John E. Toth et al. · Journal of Medicinal Chemistry · 1996 · 118 citations

Life Sciences, Biochemistry, Pharmacology +15