A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase

Edward C. Taylor, Dietmar Kuhnt, Chuan Shih, +5

Journal of Medicinal Chemistry

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

S. Betty Yan, Victoria L. Peek, Rose T. Ajamie, +19

Investigational New Drugs

Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

Chuan Shih, Lillian L. Habeck, Laurane G. Mendelsohn, +2

Advances in Enzyme Regulation

Aldo-keto ReductaseBiochemistryNatural SciencesMedicineChemical Biology +3

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

Yi‐Hui Peng, Shau‐Hua Ueng, Chen‐Tso Tseng, +16

Journal of Medicinal Chemistry

Bioorganic ChemistryAldo-keto ReductaseImidazoleisoindole DerivativesMolecular BiologyChemical Biology +15

Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

Bryan H. Norman, Chuan Shih, John E. Toth, +7

Journal of Medicinal Chemistry

Molecular RegulationWortmannin AnalogsChemical BiologyMolecular PharmacologyMedicinal Chemistry +18

Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity

Robert M. Campbell, Bryan D. Anderson, Nathan A. Brooks, +18

Molecular Cancer Therapeutics

Drug TargetAntitumor ActivityP38 MapkPharmacotherapyCancer Biology +18

Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties

Mary M. Mader, Alfonso de Dios, Chuan Shih, +27

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +6

Discovery of Cercosporamide, a Known Antifungal Natural Product, as a Selective Pkc1 Kinase Inhibitor through High-Throughput Screening

Andrea Sussman, Karen Huss, Li-Chun Chio, +16

Eukaryotic Cell

Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

Samuel Baldwin, Archie Tse, Lynn S. Gossett, +4

Biochemistry

Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery

Lun K. Tsou, Shiu‐Hwa Yeh, Shau‐Hua Ueng, +8

Scientific Reports