Lillian L. Habeck

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

C Shih, V J Chen, Lynn S. Gossett et al. · PubMed · 1997 · 565 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

Chuan Shih, Lillian L. Habeck, Laurane G. Mendelsohn et al. · Advances in Enzyme Regulation · 1998 · 144 citations

Life Sciences, Biochemistry, Pharmacology +12

Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis.

L G Mendelsohn, Chwen-Ming Shih, V. J. Chen et al. · PubMed · 1999 · 102 citations

Life Sciences, Biochemistry, Molecular Genetics +8

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs.

Lillian L. Habeck, L G Mendelsohn, C Shih et al. · Molecular Pharmacology · 1995 · 67 citations

Life Sciences, Biochemistry, Pharmacology +16

A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors.

Lillian L. Habeck, T A Leitner, Katherine A. Shackelford et al. · PubMed · 1994 · 58 citations

Medicine, Medicinal Chemistry, Pharmacology +8