Concepedia
Statistics
Publications
16
Citations
2.1K
H-Index
14
Active since
1983
Affiliations
Eli Lilly (United States)(Current)
Harvard University
Princeton University
Brigham and Women's Hospital
C Shih is an author at Eli Lilly (United States) specializing in pharmacology, medicine, and biochemistry.
Top concepts
MedicinePharmacologyBiochemistryTumor BiologyOncologyDrug DiscoveryCancer ResearchNatural SciencesMedicinal ChemistryPathology
Publications per year
1983–2024
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
C Shih, V J Chen, Lynn S. Gossett et al. · PubMed · 1997 · 565 citations
Multiple Folate-requiring Enzymes, Medicinal Chemistry, Biochemistry +14
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis.
E. J. Corey, C Shih, John R. Cashman · Proceedings of the National Academy of Sciences · 1983 · 417 citations · Full text
Docosahexaenoic Acid, Anti-inflammatory, Fish Lipid +15
Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.
T H Lee, J M Menica-Huerta, C Shih et al. · Journal of Biological Chemistry · 1984 · 304 citations · Full text
Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils.
T H Lee, Jean‐Michel Mencia‐Huerta, C Shih et al. · Journal of Clinical Investigation · 1984 · 269 citations · Full text
Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514.
Richard M. Schultz, Vinod F. Patel, John F. Worzalla et al. · PubMed · 1999 · 111 citations
Antitumor Activity, Chemoprevention Strategy, Thymidylate Synthase +16
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